Table 7: Level of Evidence Summary for CXL Management of Corneal Thinning Disorders*.
| Study Design | Number of Eligible Studies |
|---|---|
| RCT Studies | |
| Systematic review of RCTs | |
| Large RCT | |
| Small RCT | 4 |
| Observational Studies | |
| Systematic review of non-RCTs with contemporaneous controls | 2 |
| Non-RCT with contemporaneous controls | 6 |
| Systematic review of non-RCTs with historical controls | |
| Non-RCT with historical controls | 37 |
| Database, registry, or cross-sectional study | |
| Case reports | 16 |
| Retrospective review, modeling | |
| Studies presented at an international conference or other sources of grey literature | |
| Expert opinion | |
*
RCT indicates randomized controlled trial