Table 8: Topographic Outcomes in Longitudinal Pre-Post Cohorts after CXL in Treated Eyes^*.

Author, Year	Patients (eyes) Mean Age ± SD	Keratometry (K)	Pre-post 12 mo Change Mean Diopter ± SD	Pre-post P -Value
Agrawal V, 2009 (49)	25 P (37 e) 16.9 ± 3.5 yrs	K-Max K-Apex	−2.47 ± 3.89 D −2.73 ± 7.95 D	0.004 0.004
Arbelaez M, 2009 (50)	19 P (20 e) 24.4 yrs (R 18 to 44)	K- Average K- Apex	−1.36 D −1.40 D	0.004 0.01
Doors M, 2009 (52)	29 P (29 e) 35.1±11.7 yrs	Central K K-Max	0.64 ± 1.73 D − 0.29 ± 2.05 D	> 0 .05 > 0.05
El-Raggal T, 2009 (53)	9 P (15 e) 26.4 yrs (R 21 to 31)	K-Average K-Max	−1.50 D −1.75 D	< 0.001 < 0.001
Raiskup-Wolf F, 2008 (6)	130 P (142 e) 30 ± 10.5 yrs	K-Apex K-Max	−2.68± 7.61 D −1.46 ± 3.76 D	< 0. 01 < 0.01
Saffarian L, 2010 (54)	53 P (92 e) 21.5 ±3.4 yrs	Sim-K	−0.94 ± 0.71 D	< 0 .001

^*D indicates diopter; e, eyes; K, keratometry; Max, maximum; Mo, month; P, patients; R, range; SD, standard deviation; Sim, simulated; Yrs, years