Table 9: Topographic Outcomes in Longitudinal Pre-Post Cohorts after CXL in Treated and Untreated Fellow-Eyes*.
| Author, Year | Patients (eyes) Mean Age | Keratometry (K) | Treated Eye Pre-post 12 Mo Change Mean Diopter ± SD P -Value | Untreated Eye Pre-post 12 Mo Change Mean Diopter ± SD |
|---|---|---|---|---|
| Caporossi A, 2010 (41) | 44 Patients (44 e) (R, 10 to 40 yrs) |
K-Average | −1.96 ± 0.63 D P< 0. 05 | +1.2 ± 0.96 D |
| Henriquez M, 2011 (44) | 10 Patients (10 e), 10 control subjects 29.7 (R,15 to 43) yrs |
K-Max K- Min |
−2.66 D P = 0.04 −1.61 D P= 0.03 |
90% (9/10) increased K-Max |
| Koller T, 2009 (45) | 21 Patients (21 e) Age NR | Minimum corneal curvature radius | 55.0 to 54.3D P= 0 .01 | 48.6 to 49.2 D P = 0.002 |
| Leccisotti A, 2010 (46) | 51 Patients (51 e) 26.9 ± 6.3 yrs | K-Apex Sim-K |
− 0.51 ± 7.79 P > 0.05 −0.10 ± 1.44 P> 0.05 |
1.61 ± 6.28 D P > 0.05 0.88 ± 2.35 D P > 0.05 |
| Vinciguerra P, 2009 (42) | 28 Patients (28 e) (R, 24 to 52 yrs) |
K-Min K-Max |
46.10 to 40.22 D P= 0 .0003 50.37 to 44.21 D P= 0.0011 |
NR |
| Wollensak G, 2003 (7) | 22 Patients (23 e) 31.7 ±11.9 | K-Max | 2.01 ± 1.74 D P= 0.03 | NR |
*
D indicates diopter; e, eyes; K, keratometry; Max, maximum; Mo, month; NR, not reported; R, range; SD, standard deviation; Yrs, years