Table 10: Impact of CXL on Higher Order Topographic Outcomes*.
| Author Year | Patients (P) Mean Age± SD | Topographic Measure | Pre-Post Change | P -Value |
|---|---|---|---|---|
| Agrawal V, 2009 (49) | 25 P (37 e) 16.9 ± 3.5 years |
Corneal wavefront surface aberrometry | Spherical and higher order corneal aberrations did not show significant changes | > 0 .05 |
| Corneal wavefront surface aberrometry | Coma component (lower order aberrations) showed significant reduction | 0.003 | ||
| Arbelaez M, 2009 (50) | 19 P (20 e) 24.4 years |
Corneal wavefront surface aberrometry | Spherical and higher order corneal aberrations did not show significant changes | 0.041 |
| (R 18 to 44 yrs) | Corneal wavefront surface aberrometry | Absolute RMS and absolute coma were significantly reduced | 0.026 | |
| Caporossi A, 2010 (41) | 44 P (44 e) (R 10 to 40 yrs) |
Corneal wavefront surface aberrometry Surface aberrometry (CSO Eye Top) |
Total wavefront higher order aberrations were significantly reduced | < 0 .00001 |
| Corneal symmetry-Inferior-Superior-inferior index (SI) | Pre-post SI asymmetry index significantly improved | < 0.0001 | ||
| Spherical aberration remained unchanged | > 0 .05 | |||
| Doors M, 2009 (52) | 29 P (29 e) 35.1 ±11.7 years (R 19 to 76 yrs) |
Corneal aberrometry (IRX-3 Wavefront Aberrometer) | Higher-order aberration values coma-x, coma-y and spherical aberration were not significantly changed | > 0.05 |
*
e indicates eyes; Mo, month; Preop, Preoperative; R, range; RMS, root mean square; SD, standard deviation; SI, superior-inferior; Yrs, years