Table 11: Impact of CXL on Higher Order Topographic Outcomes-Comparison of Treated and Untreated Fellow-Eye*.
| Author Year | Patients (P) Mean Age ± SD | Topographic measure | Treated Eye Pre-Post Change | Untreated Fellow-Eye Pre-Post Change | Treated versus Untreated Pre-Post Change | P-Value |
|---|---|---|---|---|---|---|
| Koller T, 2009 (45) | 21 P (21 e) Age NR |
Corneal topography Pentacam system with Scheimpflug camera – Minimum corneal curvature radius (Rmin) At 12-months |
Rmim/mm 6.14 to 6.21 P= 0.01 Rmin/D 55.0 D to 54.3D P= 0.01 4 / 7 Pentacam KC indices showed significant improvements towards a more normalized corneal anterior surface Based on Rmin Change 0.12 mm ≃ 1 D Progressed: N = 0 Unchanged: N = 13 Regressed: N = 8 |
Rmin/mm 6.94 to 6.86 P= 0.002 Rmin/D48.6 D to 49.2 D P= 0.002 Based on Rmin Change 0.12 mm ≃ 1 D Progressed: N = 7 Unchanged: N = 14 Regressed: N = 0 |
Rmin/mm 0.066 ± 0.10 vs -0.08 ± 0.10 Rmin/D-0.62 ± 0.9 D vs 0.57 ± 0.8 D |
0.0009 0.0009 |
| Leccisotti A, 2010 (46) | 51 P (51 e) 26.9 ± 6.3 (R 26.9 to 39) years |
Corneal surface regularity index (ISV abnormal >37) At 12-months Tangential video keratography (Keratograph) |
ISV 76.4 ± 28.2 to 77.3 ± 28.8 Mean change 0.9 ± 4.69 (p>.05) |
ISV 48.2 ± 14.3 to 53.5 ± 19.5 Mean change 5.3 ± 7.30 (p>.05) |
ISV (95% CI) 1.99 to 6.81 |
|
| Vinciguerra P, 2009 (42) | 28 P (28 e) R 24 to 52 years |
Total (corneal and internal) wavefront analysis performed with Nidek OPD-Scan – 21-Klyce Indices | At 12-months, the Klyce indices had significantly improved (p<.05), 19 of the 21 indices improved, 1 remained the same (IAI), | At 12-months, the Klyce indices were significantly worse, none of the indices improved, 17 worsened, and 4 remained the same | ||
| In wavefront analysis, total (corneal and internal) aberrations, total higher order aberrations, total astigmatism, total coma, and total spherical aberrations were significantly decreased i.e., improved | In wavefront analysis, total astigmatism and total coma significantly increased, i.e., worsened. No significant change was noted with total, higher order or spherical aberrations |
*
D indicates diopter; e, eyes; ISV, deviation of individual corneal radii from mean values; Min, minimum; P, patients; R, range; SD, standard deviation