Table A2: Adjunct Interventions with Corneal Collagen Cross-Linking and Intrastromal Corneal Ring Segments*.
| Author, Year | Site, Country | Study Design | Population | Duration |
|---|---|---|---|---|
| Coskunseven E, 2009 (61) | Dunya Eye Hospital, Turkey | Prospective RCT − Group 1 CXL followed by ICRS implantation and Group 2 ICRS implantation followed by CXL − treatment interval was 7 months | 43 P (25 M, 18 F) − 48 e KC AC Grade 1 - 111 | 6-month |
| Chan C, 2007 (66) | Private practice, California, United States | Comparative series with matched groups: Group 1 with ICRS implantation only versus Group 2 with trans-epithelial CXL performed after ICRS implantation on the same day | 21 P − 25 e | Group 1 = 102 ± 39 days Group 2 = 97 ± 38 days |
| El-Raggal T, 2011 (63) | Ain Shams University, Cairo, Egypt | Prospective comparative series with patients undergoing CXL followed by ICRS placement 6 months later and subdivided into 3 groups based on the power settings of the femtosecond laser used in ICRS placement − Group 11,5 mJ power setting, Group 2 1.6 mJ power setting and Group 3 1.7 mJ power setting. The control group, Group 4, did not have CXL. | 20 P − 20 e Progressive grade 11-111 KC Age range 23 to 32 |
6-month |
| El-Raggal T, 2011 (62) | Ain Shams University, Cairo, Egypt | Prospective randomized comparative series with patients undergoing ICRS implanted with femtosecond laser followed by CXL performed in one session (7 e) or performed 6 months apart (9 e) | 10 P (4 M, 6 F) − 16e Progressive mild to moderate KC Mean age 27.9 ± 4.8 yrs (R, 22 to 36) |
12-months |
| Ertan A, 2009 (64) | Department of Cataract and Refractive Surgery, Kudret Eye Hospital, Turkey | Pre-post comparative cohort − ICRS implantation followed at 6 months with trans-epithelial CXL | 17 P (10 M, 5 F) − 25 e Bilateral KC Mean age 25.14yrs (R,16 to 39) |
First postop visit (after INTACS) was 3.98 months second postop visit (after CXL) was 2.67 months |
| Kamburoglu G, 2008 (121) | Kudret Eye Hospital, Turkey | Case report, ICRS implantation followed by trans-epithelial CXL the following day for postoperative LASIK ectasia | 27-year-old male Post-LASIK ectasia |
8 months |
| Vicente L, 2010 (65) | Boxer Wachler Vision Institute, California, United States | Prospective cohort, Simultaneous trans-epithelial CXL following ICRS implantation | 10 P − 14 e KC Mean age 35 ± 13 yrs (R, 13 to 58) |
3 year |
*
AK indicates Amsler-Krumeich grade; CXL indicates corneal collagen cross-linking; E indicates eye; ICRS indicates intrastromal corneal ring segment; F indicates female; KC indicates keratoconus; LASIK indicates laser in-situ keratomileusis; M indicates male; P indicates people; PMD indicates pellucid marginal degeneration; PRK indicates photorefractive keratectomy.