Table A3: Adjunct Interventions with Corneal Collagen Cross-Linking and Photorefractive Keratectomy^*.

Author, Year	Site, Country	Study Design	Population	Duration
Kanellopoulos A, 2007 (67)	Laser Vision Institute, Greece	Case report, CXL followed at 12-months by a topographically-guided PRK with untreated fellow- eye as control	26-year-old male Bilateral progressive KC	230-months
Kymionis G, 2009 (68)	Institute Vision and Optics, University of Crete Medical school, Greece	Case report, YAG laser PRK followed by CXL on the same day followed 15 days later by the procedures in the second eye	34-year-old female, bilateral KC (pellucid marginal degeneration)	12-months
Kymionis G, 2010 (70)	Institute Vision and Optics, University of Crete Medical school, Greece	Case report. Simultaneous excimer laser photorefractive keratectomy followed by CXL	24-year-old male Progressive KC	6-month
Kymionis G, 2009 (69)	Institute Vision and Optics, University of Crete Medical school, Greece	Case series, simultaneous customized topography-guided surface Nd: YAG laser ablation followed by CXL	12 p − 14 e Progressive KC Mean age 28 yrs (R, 20 to 39)	10.69 months (R, 3 to 16)
Kymionis G, 2010 (71)	Institute Vision and Optics, University of Crete Medical School, Greece	Case series, Simultaneous photorefractive keratectomy (PRK) followed by CXL	23 p − 28 e KC Mean age 30 yrs± 9.35 (R, 20 to 44)	6-month
Kymionis G, 2010 (72)	Institute Vision and Optics, University of Crete Medical School, Greece	Case reports, Simultaneous conductive keratoplasty (CK) followed within 24 hours by CXL	2 p Bilateral KC22-year-old male, 23-year-old male	6-month
Stojanovic A, 2010 (73)	Eye Dpt University Hospital of North Norway, Norway	Case series, Simultaneous topographically-guided excimer laser surface ablation followed by trans-epithelial CXL	12 p − 12 e 6 KC, 6 PMD Mean age 39.8 ± 11.9 yrs (R, 26 to 62)	12-months
Kanellopoulos A, 2011 (74)	Laser Vision Institute, Greece	Case series, Simultaneous topographically-guided partial PRK followed by CXL	22 p − 32 e Post Lasik ectasia Mean age 32 yrs (R, 23 to 66)	27-months

^*CXL indicates corneal cross-linking; KC indicates keratoconus; PRK indicates photorefractive keratectomy; R indicates range; Yrs indicates years;