Table A6: Impact of CXL on Corneal Curvature in Keratoconus – Pre-Post Longitudinal Higher Order Topographic Outcomes*.
| Author, Year | Patients (P) Mean Age± SD | Keratometric Outcome | Baseline Diopters Mean ± SD | Diopters Mean ± SD | Difference Diopters Mean ± SD | P-Value |
|---|---|---|---|---|---|---|
| Agrawal V, 2009 (49) | 25 P (37 e) 16.9 ±3.5 years | K-Max, K-Apex 12-Month(Keratron Scout, Optikon, Italy) | 53.26 ± 5.93 D | −2.47 ± 3.89 D −2.73 ± 7.95 D K-Max summary Decreased (± 1.0D) 54% (20/37) Stable (± 0.5D) in 38%(14/37) Worse (>-1.0 D) 8% (3/37) |
0.004 0.004 |
|
| Corneal wavefront surface aberrometry | Spherical and higher order corneal aberrations did not show significant changes Coma component (lower order aberrations) showed significant reduction |
Coma 0.003 | ||||
| Arbelaez M, 2009 (50) | 19 P (20 e) 24.4 (R,18 to 44) years |
K- Average K- Apex at 12-months |
49.93 ± 5.02 D 51.89 ± 7.99 D |
48.57 ± 4.54 D 50.42 ± 8.09 D |
1.36 D 1.40 D |
0.004 0.01 |
| Corneal wavefront surface aberrometry | Spherical and higher order corneal aberrations did not show significant changes Absolute RMS and absolute coma were significantly reduced |
0.041 0.026 |
||||
| Doors M, 2009 (52) | 29 P (29 e) 35.1 ±11.7 years (R, 19 to 76) |
Central K K-Max at 6 months Corneal topography (Eye map), Pentacam HR tomography (Oculus), |
Mean central K and K-Max were not significantly changed | > 0.05 | ||
| Corneal aberrometry (IRX-3 Wavefront Aberrometer) | Coma-x −0.05 ± 0.38 µm Coma-y -0.19 ± 0.92 µm Spherical aberration 0.12 ± 0.27 µm |
−0.19 ± 0.39 µm −1.10 ± 0.91 µm 0.07 ± 0.30 µm |
Higher-order aberration values coma-x, coma-y and spherical aberration were not significantly changed | > 0.05 | ||
| El-Raggal T, 2009 (53) | 9 P (15 e) 26.4 (R, 21 to 31) years |
K-average | 47.77 ± 1.79 D (R, 44.8 to 50.1) |
46.27 ± 1.66 D (R, 43.6 to 48.7) |
<0.001 | |
| K-Max At 6 months |
52.17 ± 1.66 D (R, 49.2 to 54.1) |
50.42 ± 1.57 D (R, 47.9 to 52.7) |
<0.001 | |||
| Corneal topography (TMS-4 Tomey Inc) | ||||||
| Raiskup-Wolf F, 2008 (6) | 130 P (142 e) 30 ± 10.5 years |
K-Apex | −2.68± 7.61 D | <0 .01 | ||
| K-Max At 12-months |
−1.46 ± 3.76 D | <0.01 | ||||
| K-Apex decreased in 62% eyes, remained stable in 17% and increased in 21 | ||||||
| Saffarian L, 2010 (54) | 53 P (92 e) 21.5 ±3.4 (R,16 to 30) years |
Sim-K Corneal topography by Orbscan 11 − |
46.94 ± 2.37 D | 46.0 ± 2.33 D | 0.94 ± 0.71 D | < 0.001 |
*
E indicates eye, K indicates keratometry; Max indicates maximum; P indicates people.