TABLE 1: BASELINE VISUAL ACUITY OF KERATOCONUS PATIENTS IN THE CLEK COHORT STUDY*

TABLE 2: BASELINE VISUAL CORRECTION IN PATIENTS IN CLEK COHORT STUDY*

TABLE 3: PATIENT-BASED TIME TRADEOFF UTILITY VALUES ASSOCIATED WITH VISUAL ACUITY LEVELS IN THE BETTER SEEING EYE

TABLE 4: PATIENT-BASED TIME TRADEOFF UTILITY VALUES ACROSS DISEASE STATES

TABLE 5: REPORTS OF OTHER INDICATIONS FOR CORNEAL COLLAGEN CROSS-LINKING*

TABLE 6: EVIDENCE BASE FOR CXL FOR CORNEAL THINNING DISORDERS*

TABLE 7: LEVEL OF EVIDENCE SUMMARY FOR CXL MANAGEMENT OF CORNEAL THINNING DISORDERS*

Table 8: TOPOGRAPHIC OUTCOMES IN LONGITUDINAL PRE-POST COHORTS AFTER CXL IN TREATED EYES*

TABLE 9: TOPOGRAPHIC OUTCOMES IN LONGITUDINAL PRE-POST COHORTS AFTER CXL IN TREATED AND UNTREATED FELLOW-EYES*

TABLE 10: IMPACT OF CXL ON HIGHER ORDER TOPOGRAPHIC OUTCOMES*

TABLE 11: IMPACT OF CXL ON HIGHER ORDER TOPOGRAPHIC OUTCOMES- COMPARISON OF TREATED AND UNTREATED FELLOW-EYE*

TABLE 12: CHANGE IN REFRACTIVE SPHERE AT 12-MONTHS FOLLOWING CXL FOR KERATOCONUS*

TABLE 13: CHANGE IN REFRACTIVE CYLINDER AT 12-MONTHS FOLLOWING CXL FOR KERATOCONUS*

TABLE 14: IMPACT OF CXL ON BEST CORRECTED VISUAL ACUITY AT 12-MONTHS*

TABLE 15: TREATMENT FAILURE ASSESSED BY TOPOGRAPHIC OUTCOME MEASURES AT 12-MONTHS*

TABLE 16: CXL TREATMENT OF KERATECTASIA AFTER LASER IN-SITU KERATOMILEUSIS*

TABLE 17: ADJUNCT PROCEDURES WITH CXL INVOLVING INTRASTROMAL CORNEAL RING SEGMENTS

TABLE 18: ADJUNCT PROCEDURES WITH CXL INVOLVING PHOTOREFRACTIVE KERATECTOMY*

TABLE 19: COMPLICATION CASE REPORTS FOLLOWING CXL IN KERATOCONUS*

TABLE 20: CORNEAL STROMAL HAZE AFTER CXL

TABLE 21: PACHYMETRY MEASURES OF CENTRAL CORNEAL THICKNESS IN KERATOCONUS FOLLOWING CXL*

TABLE 22: CHANGE IN INTRAOCULAR PRESSURE FOLLOWING CXL*

TABLE 23: IMPACT OF CXL ON ENDOTHELIAL CELL DENSITY*

TABLE 24: IMPACT OF CXL ON CRITICAL OCULAR STRUCTURES*

TABLE 25: GRADE QUALITY OF EVIDENCE FOR CXL OF KERATOCONUS*

TABLE 26: PHYSICIAN AND CLINIC COSTS ASSOCIATED WITH CXL THERAPY FOR KERATOCONUS IN ONTARIO

TABLE 27: TOTAL ANNUAL COSTS OF CXL FOR KERATOCONUS – ESTIMATED PHYSICIAN, CLINIC AND MEDICATION COSTS*

TABLE A1: EFFECTIVENESS REPORTS OF CORNEAL COLLAGEN CROSS-LINKING OF KERATOCONUS*

TABLE A2: ADJUNCT INTERVENTIONS WITH CORNEAL COLLAGEN CROSS-LINKING AND INTRASTROMAL CORNEAL RING SEGMENTS*

TABLE A3: ADJUNCT INTERVENTIONS WITH CORNEAL COLLAGEN CROSS-LINKING AND PHOTOREFRACTIVE KERATECTOMY*

TABLE A4: SAFETY STUDIES OF CORNEAL COLLAGEN CROSS-LINKING*

TABLE A5: COMPLICATION CASE REPORTS FOR CORNEAL COLLAGEN CROSS-LINKING*

TABLE A6: IMPACT OF CXL ON CORNEAL CURVATURE IN KERATOCONUS – PRE-POST LONGITUDINAL HIGHER ORDER TOPOGRAPHIC OUTCOMES*

TABLE A7: IMPACT OF CXL ON CORNEAL CURVATURE IN KERATOCONUS – HIGHER ORDER TOPOGRAPHIC FINDINGS IN TREATED AND UNTREATED FELLOW-EYES*