Table 10. Major Adverse Events in RCT of RFA vs. Surgery.

Author, Study Size (RFA, Surgery)	Follow-Up	RFA Major Adverse Events*	Surgery Major Adverse Events
Hinchliffe et al., 2006	6 week F-UP	0	1 superficial post-operative wound infection
N = 16 pairs, recurrent VV			1 persistent thrombophlebitis
Lurie et al., 2003, 2005 N = 43, 36	3 week F-Up	3 surgical wound thrombosis	4 infections 4 surgical wound thrombosis
Rautio et al., 2002 N = 15, 13	2 month F-Up	3 clinical thrombophlebitis 1 thermal skin injury	0
Perala et al., , 2005 of Rautio’s trial	3 Yr F-Up	1 saphenous nerve injury 1 extended period superficial thrombophlebitis	5 saphenous nerve injuries
Stotter et al., 2006 N = 20, 40	6 Week F-Up	0	0
Subramonia et al., 2009 N = 48, 45	5 week F-Up	0	0
Total = 292 (142,150)		9 (6.3%) 95% CI; 3.4% - 11.6%	17 (11.3 %) 95% CI; 7.2% - 17.4%

*Major adverse events include deep venous thrombosis,, pulmonary embolism,, thermal injury, or saphenous vein injury