Table 3: Quality of Evidence of Included Studies.
| Study Design | Level of Evidence† | Number of Eligible Studies |
|---|---|---|
| Large RCT, systematic review of RCTs | 1 | |
| Large RCT unpublished but reported to an international scientific meeting | 1(g) | |
| Small RCT | 2 | |
| Small RCT unpublished but reported to an international scientific meeting | 2(g) | |
| Non-RCT with contemporaneous controls | 3a | |
| Non-RCT with historical controls | 3b | |
| Non-RCT presented at international conference | 3(g) | |
| Surveillance (database or register) | 4a | |
| Case series (multisite) | 4b | |
| Case series (single site) | 4c | Jonas et al. 2007 (24 hour curve) Bergea et al. 1999 (diurnal curve) AGIS (single measurement) DIGS (single measurement) |
| Retrospective review, modelling | 4d | EMGT (single measurement) Choi et al. (24 hour curve) Bengtsson et al. (diurnal curve) |
| Case series presented at international conference | 4(g) Total |
7 |
RCT refers to randomized controlled trial; g refers to grey literature.