Table 12: Summary of Studies Using a 24-Hour Curve for IOP Measurement.

Study, Year	Design	Population	Objective	IOP Parameters	Statistical Method	Timing of IOP Measurement	Results	Comment
Jonas et al. 2007 (25)	Unclear if retrospective or prospective observational analysis. 855 eyes	Chronic OAG NTG=174 eyes High pressure OAG=681 eyes	To evaluate whether the amplitude of day and night IOP profiles influence the rate of progression of chronic OAG.	Mean Fluctuation Peak	Multiple Cox proportional hazard regression	At least 2 IOP curves with measurements 5pm, 9pm, midnight, 7am and noon.	Median followup=51.5 months; range 5.4 to 124.9 months 163/855 eyes showed progression. High Pressure OAG Progression significantly associated with age (P>0.001), not mean IOP or amplitude. NTG Progression significantly associated with higher mean IOP(P=0.04), but not amplitude (P=0.05).	All patients were on routine ophthalmic care including topical application of antiglaucoma drugs.
Choi et al. 2007 (24)	Retrospective chart review 113 eyes	NTG No previous or current use of antiglaucoma drugs	To investigate systemic and ocular hemodynamic risk factors for glaucomatous damage in eyes with NTG.	Mean Fluctuation Peak	Multivariate regression	Every 2 hours between 12pm and 10am, except for the period between 12am and 6am when measurements were every 3 hours.	Mean IOP, peak IOP and fluctuation were not significantly associated with VF or optic disc worsening (p<0.05).	Patients on hypertension or other hemodynamically active drugs not excluded.

IOP refers to intraocular pressure; NTG, normal tension glaucoma; OAG, open angle glaucoma; RCT, randomized controlled trial; SD, standard deviation; VF, visual field