Outcome	Number of studies	Design	Quality	Consistency	Directness	Other Modifying Factors	Grade
Primary outcome: Proportion of patients who achieved 100% wound closure within 16 weeks	2	RCT	Moderate	No uncertainty	No uncertainty	N/A	Moderate
Secondary outcome: Median time to 100% wound closure	2	RCT	Moderate	No uncertainty	No uncertainty	N/A	Moderate