Table 4: Results of Studies on Diabetic Wounds.
| Complete (100%) wound closure within 16 weeks N (%) | Median time to complete wound closure* Day (95% CI) | 75% wound closure within 112 days of active treatment without need for drainage or dressing N (%) | Median time to 75% wound closure* Day (95% CI) | Decrease in wound area from the baseline on day 28 cm2 | 76%-100% granulation tissue formation on patients with 0% to 10% granulation at the baseline N (%) | Median time to 76%-100% granulation tissue formation* Day (95% CI) | |
|---|---|---|---|---|---|---|---|
| Blume et al. (4) | NPWT: 73/169 (43.2) Control: 48/166 (28.9) P = .007 Surgically closed NPWT: 16/169 (9.5%) Control: 14/166 (8.4%) |
NPWT: 96 (75-114) Control: Not estimable P = .001 |
NPWT: 105/169 (62.1) Control: 85/166 (51.2) P = .044 |
NPWT: 58 (53-78) Control: 84 (58-89) P = .014 |
NPWT: -4.32 Control: -2.53 P = 0.021 |
NPWT: 17/24 (70.8) Control: 8/22 (36.4) P = .019 |
NPWT: 56 (42-84) Control: 114 (44 –ND) P = .022 |
| Armstrong et al. 2005 (6) | NPWT: 43/77 (56) Control: 33/85 (39) P = .04 Surgically closed NPWT: 12 (16%) AMWT: 8 (9%) P = .244 Healed without surgical closure: NPWT: 31 (40%) AMWT: 25 (30%) |
NPWT: 56 (26-92) Control: 77 (40-112) P = .005 |
NR | NR | NR | NR | NPWT: 42 (40-56) Control: 84 (57-112) P = .002 Note: Similar results for those who had 0-25% granulation at baseline (P = .01) |
NPWT, Negative pressure wound therapy; ND, Not determined