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. Author manuscript; available in PMC: 2012 Jun 18.
Published in final edited form as: Exp Biol Med (Maywood). 2008 Mar 28;233(5):507–521. doi: 10.3181/0710-MR-287

Figure 1.

Figure 1

Representation of the spliced events affecting initiation of translation (A) and the fatty acid Gate domains (B). (A) Cartoon showing the exon-intron organization of the 5′-end of the ACSL genes, corresponding spliced variants (mRNA) and their products. The long isoforms start at the first AUG codon (AUG1, Met1) and the short isoform at the second AUG codon (AUG2, Met2). Note that two isoforms of ACSL3 are generated from the same mRNA. No variation has been reported for ACSL1. (B) Representation of the exclusive-exon pair encoding the two versions of the fatty acid Gate-domains (F- and Y-Gate) downstream of the exon encoding the ATP-binding site (P-loop). ACSL3, ACSL4, and ACSL5 genes lack the F-exon and encoded only the Y-Gate-domain version.

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