Table 1.
The Mammalian ACSLsa
| Characteristics | Spliced transcript variant | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | Alternative elements |
Isoforms | Length (aa) | Human | Mouse | Rat | |||
| ACSL1 | F,Y-exon | Y-exon | 698 | v1 | DQ083029 | ||||
| F-exon | 698/699b | v2 | NM_001995.2 | NM_007981.3 | NM_012820.1 | ||||
| no F,Y-exon | 672 | v3 | DQ083028 | ||||||
| ACSL3 | 5′-UTRs | 720 | v1 | NM_004457.3 | v1 | NM_028817.2 | NM_057107.1 | ||
| 720 | v2 | NM_203372.1 | v2 | NM_001033606.1 | |||||
| ACSL4 | 5′-UTRs / AUGs | AUG2 | 670 | v1 | NM_004458.1 | v3 | NM_001033600.1 | ||
| 670 | v2 | NM_019477.3 | NM_053623.1 | ||||||
| AUG1 | 711 | v2 | NM_022977.1 | v1 | NM_207625.2 | ||||
| ACSL5 | 5′-UTRs / AUGs | AUG1 | 739 | v1 | NM_016234.3 | ||||
| AUG2 | 683 | v2 | NM_203379.1 | NM_027976.2 | NM_053607.1 | ||||
| 683 | v3 | NM_203380.1 | |||||||
| ACSL6 | 5′-UTRs / AUGs / exon8 / F,Y-exon |
AUG1 / Y-exon | 722 | v1 | NM_015256.2 | v2 | NM_001033597.1 | EF490998c | |
| AUG1 / F-exon | 722 | v2 | NM_001009185.1 | v1 | NM_144823.4 | ||||
| AUG2 / Y-exon | 697 | v4 | NM_001033599.1 | v1 | NM_130739.1 | ||||
| AUG2 / F-exon | 697 | v3 | NM_001033598.1 | v2 | AY625254.1 | ||||
| AUG2 / no F,Y-exon | 622 | v3 | BC047453.1 | ||||||
| AUG? / ΔF-exon | d | v4 | DQ083030 | ||||||
| AUG2 /Ex.8 / F-exon | 712 | v5 | DQ083031 | ||||||
a
GenBank accession numbers of the various spliced variants of the five ACSL members. Alternative elements are 5′-UTRs, translational codon initiators (AUG1, AUG2), alternative exon (exon 8 of ACSL6), exclusive exon pair encoding the Y-Gate and the F-Gate domain (Y-exon, F-exon). Isoforms without Gate-domain are indicated as no F,Y-exon and isoform with truncated F-Gate domain as ΔF-exon. Length of the product of each spliced variant is indicated (aa, amino acid).
b
ACSL1 form of rodent is one residue longer than the form of other mammals (see text and Fig. 4).
c
Partial cDNA sequence (see text and Fig. 7).
d
The full-length sequence of variant 4 of ACSL6 is not known.