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. 2012 Jun 18;7(6):e38979. doi: 10.1371/journal.pone.0038979

Figure 1. The top 10 frequently used Pfam domain families for known MFEs.

Figure 1

It is noted that about 17% of SMAD-MFEs contain ArgJ. It plays key role in both N-acetylglutamate synthase and ornithine acetyltransferase activities in the cyclic version of arginine biosynthesis.