Table 2. The statistics of MFEs by number of KEGG biological pathways they are involved in.

Num# of Pathways	MCD-MFEs		SMAD-MFEs		MFEs of Archaea		MFEs of Bacteria		MFEs of Eukaryota
	Num#	PCT*(%)	Num#	PCT*(%)	Num#	PCT*(%)	Num#	PCT*(%)	Num#	PCT*(%)
1	2,377	57.65	729	89.78	24	22.02	2,764	63.64	317	65.63
2	1,388	33.66	53	6.53	78	71.56	1,277	29.40	86	17.81
3	89	2.16	7	0.86	0	0	56	1.29	40	8.28
4	37	0.90	13	1.60	0	0	39	0.90	11	2.28
5 and more	232	5.63	10	1.23	7	6.42	206	4.74	29	6.00

Num^#: Number; PCT^*: Percentage.

Totally, 4,123 known MCD-MFEs and 812 known SMAD-MFEs were included in this statistics, covering 109, 4,343, and 483 known MFEs were respectively in Archaea, Bacteria and Eukaryota respectively.