Table 4. Functional classification of affected genes at high dose.

GO ID	GO Processes	Carcinogens*
		AA	BA	BZ	EDB	EPI	HQ	SO	ST	TCE
GO:0030503	Regulation of cell redox homeostasis	P	P	O	P	O	O	O	P	O
GO:0042789	mRNA transcription from RNA polymerase I	P	O	P	P	P	P	O	O	O
GO:0007050	Cell cycle arrest	P	O	P	O	P	P	O	P	O
GO:0032792	Inhibition of CREB transcription factor	P	O	O	P	O	P	O	P	O
GO:0043065	Positive regulation of apoptosis	P	O	P	O	P	O	O	P	O
GO:0001975	Response to amphetamine	P	O	P	O	O	P	O	P	O
GO:0001711	Endodermal cell fate commitment	O	P	O	O	P	P	O	O	P
GO:0006450	Regulation of translational fidelity	O	P	O	O	P	P	O	O	P
GO:0015855	Pyrimidine transport	O	P	O	O	P	O	P	O	P
GO:0030858	Positive regulation of epithelial cell differentiation	O	P	O	O	P	P	O	O	P

Functional classification of significantly affected genes by exposure to carcinogens at high dose into Gene Ontology (GO) categories was performed. GO categories that were affected by 4 or more carcinogens per chemical dose are listed. A list of all GO categories affected per chemical per dose is given in the supplementary Table S2.

^*Carcinogens [AA:Acrylamide; BA:Benz[a]anthracene; BZ:Benzene; EDB:Ethylenedibromide; EPI:Epichlorohydrin; HQ:Hydroquinone; SO:Styrene 7,8-oxide; ST:Styrene; TCE:Trichloroethylene].