Figure 3. Connectivity maps of significantly increased (red) and decreased (blue) cerebellar-cerebral functional connectivity in the adults with major depression, visualized using CARET 5.62 [58], [59]: (A and B) Left hemisphere, (C and D) Right hemisphere.

Relative to the controls, the depressed patients showed a significant connectivity increase between the cerebellum and the temporal poles and left middle frontal cortex as well as a significant connectivity decrease between the cerebellum and the default-mode network, mainly including the ventromedial prefrontal cortex and posterior cingulate cortex/precuneus.