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. 2012 Jun 18;7(6):e39497. doi: 10.1371/journal.pone.0039497

Figure 2. Early time-dependent enhanced production of TNFalpha, IL-1beta, and MIP-1alpha by HZ-fed human adherent monocytes.

Figure 2

Cells were unfed (CTR cells) (Panel A), fed with latex particles (latex-fed cells) (Panel B), or fed with HZ (HZ-fed cells) (Panel C) for 2 h; afterwards, production of TNFalpha, IL-1beta, and MIP-1alpha was monitored every 30 min in cell supernatants up to 2 h. Data are means + SEM of three independent experiments. Production of pro-inflammatory molecules is indicated as pg/ml. All data were evaluated for significance by ANOVA. HZ-fed vs CTR cells: *p<0.0001 for TNFalpha (120 min); °p<0.01 for IL-1beta (60 min), °°p<0.0001 for IL-1beta (90 and 120 min); §p<0.001 for MIP-1alpha (60 min), §§p<0.0001 for MIP-1alpha (90 and 120 min).