Table 1. Attenuation of proinflammatory cytokine production by NaPB in primary mouse microglia.
Cytokine (ng/mgprotein/24 h) | Treatment | |||||
Control | LPS | LPS+NaPB (0.1 mM) | LPS+NaPB (0.2 mM) | LPS+NaPB (0.5 mM) | NaPB (0.5 mM) only | |
TNF-α | 0 | 18.4+3.1 | 16.8+1.5 | 12.7+0.8 | 8.6+1.1a | 0 |
IL-1β | 0 | 11.2+2.9 | 9.9+1.4 | 7.5+1.1 | 5.3+0.6a | 0 |
Primary microglia preincubated with different concentrations of NaPB for 6 h were stimulated with LPS for 24 h followed by quantification of TNF-α and IL-1β in supernatants by ELISA. Results are mean + SD of three independent experiments.
p<0.001 vs LPS.