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. 2012 Jun 18;7(6):e38868. doi: 10.1371/journal.pone.0038868

Table 1. Quantification of telomerase activity and hTERT alternative splicing variants in tumor cell lines.

Cell lines Source Telomerase activity*(TPG units) hTERT overall transcripts# hTERT alternative splicing variants
Relative expression# Constituent ratio
α-deletiontranscripts β-deletiontranscripts γ-deletiontranscripts α-deletiontranscripts β-deletiontranscripts γ-deletiontranscripts
A549 Lung adenocarcinoma 31.43±6.47 17.00±2.92 4.25±2.14 2.44±0.68 Not found 0.25 0.14 Not found
SPC-A1 Lung adenocarcinoma 14.22±9.27 15.14±2.70 3.22±0.81 3.97±0.81 0.61±0.04 0.21 0.26 0.04
H1299 Lung large cell carcinoma 20.37±2.76 5.61±0.88 2.44±1.62 0.46±0.02 Not found 0.44 0.08 Not found
PAa Lung adenocarcinoma 21.42±3.57 14.80±3.73 4.25±1.17 1.98±1.61 Not found 0.29 0.13 Not found

hTERT: human telomerase reverse transcriptase.

*

The means±standard deviation of duplicate determinations.

#

The means±standard deviation of triplicate determinations.

It was calculated by dividing the relative expression value of the overall transcripts by that of each deletion.