Skip to main content
. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Mucosal Immunol. 2012 Mar 14;5(4):397–408. doi: 10.1038/mi.2012.17

Figure 3. Genetic deletion of MyD88 decreases neonatal survival and increases lung bacterial burden in WT and Scnn1b-Tg+ mice.

Figure 3

(a) Survival curves. Absence of MyD88 in Scnn1b-Tg+ mice lowers survival. ANOVA * p = 0.004 vs. littermates. (b) Representative photomicrograph of BAL cytospin preparations from neonatal MyD88-sufficient and -deficient Scnn1b-Tg+ mice, illustrating mucus-associated bacteria in MyD88−/−;Scnn1b-Tg+ mice. Scale bar = 10 μm. (c) Bacterial CFU in mice from the MyD88−/− × Scnn1b-Tg+ cross at the ages indicated, (Log10+1)-transformed data. n= number of mice/group. ANOVA ** p<0.005, * p<0.05 vs. MyD88+/−;Scnn1b-Tg− mice. # p<0.05 vs. MyD88+/−;Scnn1b-Tg+ mice. (d) Lung microflora in mice from the MyD88−/− × Scnn1b-Tg+ cross. Each tick on the x axis represents an individual mouse.