Skip to main content
. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Mucosal Immunol. 2012 Mar 14;5(4):397–408. doi: 10.1038/mi.2012.17

Figure 4. Genetic deletion of MyD88 reduces lung neutrophilia in Scnn1b-Tg+ mice, but does not blunt macrophage activation.

Figure 4

(a–d) Differential BAL cell counts. n= 8, 9, 8, 8 at 5 days (5d), n= 14, 9, 12, 12 at 10 days (10d), n= 5, 5, 5, 9 at 4 weeks (4wk), and n= 3, 6, 7, 8 at 8 weeks (8wk) for MyD88+/−;Scnn1b-Tg-, MyD88−/−;Scnn1b-Tg-, MyD88+/−;Scnn1b-Tg+, and MyD88−/−;Scnn1b-Tg+ mice, respectively. ANOVA ** p<0.005, * p<0.05 vs. MyD88+/−;Scnn1b-Tg− mice. # p<0.05 vs. MyD88+/−;Scnn1b-Tg+ mice. (e) Macrophage size distribution in 4 week-old mice from the MyD88−/− × Scnn1b-Tg+ cross. Boxed regions highlight the percentage of total macrophages larger than the 90th percentile in MyD88+/−;Scnn1b-Tg− mice. n=5 MyD88+/−;Scnn1b-Tg-, 4 MyD88−/−;Scnn1b-Tg-, 5 MyD88+/−;Scnn1b-Tg+, and 8 MyD88−/−;Scnn1b-Tg+. ANOVA ** p<0.005, * p<0.05 vs. MyD88+/−;Scnn1b-Tg-littermates.