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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Free Radic Biol Med. 2012 May 9;53(1):44–50. doi: 10.1016/j.freeradbiomed.2012.04.031

Fig. 2. SOD2 knockdown inhibits both the migration and invasion abilities of TSCC.

Fig. 2

To characterize the role of SOD2 in aiding metastasis, the plasmid containing SOD2 shRNA was transiently transfected into UM1 cells using Lipofectamine Plus reagent. Cells were tested 24 h post-transfection.

(A) Significant reduction of SOD2 protein levels and activities were observed in the SOD2 shRNA-transfected UM1 cells compared to the vector control transfected cells. *: P< 0.05.

(B, C) SOD2 knockdown inhibited the migration and invasion of UM1 cells. *: P< 0.05.

(D) UM1 cells displayed a significant decrease in H2O2 production after transfecting with the SOD2 shRNA. *:p< 0.05.

(E) The cell proliferation rate of the UM1 line was significantly inhibited after transfecting with the SOD2 shRNA. *: P< 0.05.