Table 2.
Patient | Pathology Diagnosis | Banff Classification and Scoring | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
g | i | t | v | ah | cg | ci | ct | cv | mm | ptc | c4d | ||
1 | Mild interstitial fibrosis; patchy tubular atrophy | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 1 | 1 | 1 | 0 | 0 |
2 | Mod interstitial fibrosis; tubular atrophy | 0 | 1–2 | 0 | 0 | 0 | 2 | 2 | 2 | 2 | 1 | 0 | 0 |
3 | Inadequate biopsy sample consisting of mostly renal medulla. (on LM comment, tubules showed no significant interstitial changes) | na | na | na | na | na | na | na | na | na | na | na | na |
4 | Mod interstitial fibrosis; tubular atrophy >30% cortex | 2 | 0 | 0 | 0 | 3 | 2 | 2 | 2 | 1 | 0 | 3 | 0 |
5 | Mild interstitial fibrosis and tubular atrophy | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
6 | Mild interstitial fibrosis and tubular atrophy; (additional comment: borderline cellular rejection except severe tubulitis in inflamed area) | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | NRa | 0 | 0 |
7 | No significant interstitial fibrosis or tubular atrophy; minimal focal inflammation | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NR | 0 | NR |
8 | Mild interstitial fibrosis and tubular atrophy | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 2 | 0 | 0 | NR |
9 | Mild tubular atrophy and interstitial fibrosis (15% cortex) | 0 | 0 | 0 | 0 | 2 | 3 | 1 | 1 | 2 | NR | 0 | 0 |
10 | Mild interstitial fibrosis and tubular atrophy. | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | NR | 0 | NR |
Pathology reports including the Banff scores yielded six patients with a diagnosis of mild interstitial fibrosis, two patients with moderate (mod) interstitial fibrosis, one patient with no significant intersitial fibrosis, and one patient with an inadequate tissue specimen for pathological evaluation (na). Some of the Banff scores were not directly reported in the pathology report and are noted (aNR not reported). Banff scoring provides quantitative criteria for early type of allograft glomerulitis (g), mononuclear cell interstitial inflammation (i), tubulitis (t), intimal arteritis (v), arteriolar hyaline thickening (ah), allograft glomerulopathy (cg), interstitial fibrosis (ci), tubular atrophy (ct), fibrous intimal thickening (cv), mesangial matrix increase (mm), peritubular capillaries (ptc), and c4d and/or immunoglobulin in peritubular capillaries (c4d) (10).