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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Free Radic Biol Med. 2012 May 1;53(1):51–59. doi: 10.1016/j.freeradbiomed.2012.04.024

Figure 3.

Figure 3

Frequency of incorporation of the oxidized nucleotide 8-oxoG in the G4 region of multiple promoters in hypoxia. ChIP was used to detect changes in level of incorporation of 8-oxoG between cells in normoxia and various periods of hypoxia (1, 3, or 6 hours) in the regions of promoters that contain predicted G4 sequences of genes that were determined to be down-regulated (A), up-regulated (B), or transcriptionally unaffected (C) by hypoxia. Each line represents an independent cell culture and chromatin preparation for ChIP.