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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Free Radic Biol Med. 2012 Apr 19;52(0):2223–2233. doi: 10.1016/j.freeradbiomed.2012.04.003

Fig. 1. Time course of age-dependent spermatogenic impairment in mutant males.

Fig. 1

(A–B). Spermatogenic development is normal in prepubertal mutant mice. In the testes of 35-day-old controls (A) and mutants (B), elongated spermatids in the seminiferous lumen were both observed. (C–D). Normal spermatogenesis in 7-month-old control (C) and mutant (D) mice. E. Qualitatively normal spermatogenesis in 9-month-old mutants. F. Qualitatively normal spermatogenesis in 10-month-old mutants. G. Some mutant mice of 10.5 months start to show degenerated seminiferous tubules. H. Impaired spermatogenesis in 11-month-old mutants. I. Impaired spermatogenesis in 15-month-old mutants. J. Normal spermatogenesis in 15-month-old control males. Scale bars in A–B: 50 μm; scale bars in C–J: 100 μm.