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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Pain. 2012 May 19;153(7):1514–1524. doi: 10.1016/j.pain.2012.04.015

Figure 1.

Figure 1

The effects of intramuscular injection of NMDA and AMG 9810 on masseter mechanical sensitivity. (A) Changes in mechanical sensitivity following NMDA, PBS or AP5 followed by NMDA administration in the masseter muscle. (B) NMDA-induced changes in mechanical sensitivity following pretreatment of the masseter with AMG 9810, a specific TRPV1 antagonist, or vehicle. (C) The effects on AMG9810 administered in the masseter contralateral to the NMDA treatment or AMG9810 alone on masseter mechanical sensitivity. (D) The effects of AMG9810 (100 nmol) on mustard oil-induced mechanical hyperalgesia. (*, p < 0.05 in group effects with respect to vehicle condition in two-way ANOVA; #, p < 0.05 to the baseline in post-hoc test; n = 6-8 for each group).