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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Pain. 2012 May 19;153(7):1514–1524. doi: 10.1016/j.pain.2012.04.015

Figure 7.

Figure 7

PKA is not involved in NMDA-induced TRPV1 phosphorylation. (A) KT5720, a PKA inhibitor, or vehicle control failed to prevent the NMDA-induced elevation of p-Ser of TRPV1 (*, p < 0.05 in one-way ANOVA; n = 6-8 per group in A and B). (B, C) NMDA-induced mechanical hyperalgesia was only partially attenuated at the dose that completely blocked the forskolin induced mechanical hyperalgesia (*, p < 0.05 in group effects with respect to vehicle condition in two-way ANOVA; #, p < 0.05 to the baseline in post-hoc test; n = 6-8 per group).