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. 2011 Aug 30;22(7):1520–1529. doi: 10.1093/cercor/bhr223

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© The Authors 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Hippocampal slices from NRG1^{tg-type I} mice are prone to carbachol-induced epileptiform activity. (A) Sample field potentials during baseline (top trace) and following application of 20 μM carbachol (CCh; middle and bottom traces) in slices from NRG1^{tg-type I} mice. The lower 2 panels show examples of carbachol-evoked epileptiform field potential discharges resembling ictal and interictal-like bursts. (B) Pie charts illustrate the percentage of slices in which cholinergic activation (5–20 μM carbachol) results in robust gamma oscillations (empty segment) or immediate field epileptiform activity (filled segment). The proportion showing epileptiform activity is higher in slices from NRG1^{tg-type I} mice than wt mice (Fisher’s exact test, P < 0.0001).