Table 1. Summary of the frequency of Flt3-ITD mutations, chromosome 2 deletions and Sfpi1/PU.1 R235 point mutations in a panel of 30 radiation-induced AMLs induced on two different genetic backgrounds.
AML genetic background | Del2 | Number of samples | Number with Flt3-ITD (%) | Number with Sfpi-1/PU.1 exon 5 mutation (%) |
---|---|---|---|---|
CBA/H × C57BL | + | 17 | 0 (0.0) | 14 (82.4) |
− | 3 | 2 (66.7) | 0 (0.0) | |
CBA/H | + | 6 | 0 (0.0) | 5 (83.3) |
− | 4 | 1 (25) | 0 (0.0) |
Abbreviations: AML, acute myeloid leukaemia; Del2, chromosome 2 deletion.