Table 4.
Species-specific variations in circulating ChE activities.
| Bovine | Macaque | Mouse | |||
|---|---|---|---|---|---|
| Fetal | Adult | Rhesus | wt (C57BL) | mdx | |
| Total ChE (no inhibitor) | 5020 | 470 | 2240 | 3500 ± 210 | 3260 ± 270 |
| BChE (+BW) | 190 | 100 | 1990 | 2140 ± 90 | 1650 ± 220 |
| AChE (+iso-OMPA) | 4830 | 370 | 250 | 910 ± 40 | 1260 ± 130 |
| BuChE/AChE | 0.04 | 0.27 | 3.9 ± 0.4 | 2.3 ± 0.2 | 1.3 ± 0.5 |
| AChE U/mL* | 1.2–1.7 | 0.11 | 0.081 | 0.24 | 0.35 |
All sera were from male animals. ChE activities were determined by radiometric assay with ACh and the respective inhibitors, and presented as units in 125 μL serum. Macaque and bovine values were obtained from pooled sera of three animals each. The values observed for bovine sera were confirmed by Drs. B. P. Doctor and H. Saxena (Walter Reed Army Institute of Research, Silver Spring, MD, pers. communication).
*
AChE U/mL values represent activities calculated in enzyme units (U = μmoles ACh hydrolyzed/min).