Fig. 2.

Microscopic properties of Mg²⁺ -inhibited cation channel in Jurkat T lymphocytes. Channel activity in 10 HEDTA basal solution with no added Mg²⁺ in inside-out patch configuration. A: 2 large conductance (γ₁) open channel states are seen. Measurement taken at −90 mV. B: membrane patch showing the activity of one large conductance (γ₁) and one small conductance (γ₂) channel activity measured at −100 mV. C: large conductance TRPM7 channel unitary currents in the outward direction measured at +90 mV. All points histograms corresponding to the current traces are at bottom. Numbers shown in histograms represent means ± SD obtained from Gaussian fits.