Table II.
Proportion of individuals with T cell or NK cell CD69, IFN-γ or CD25 responses1 to HBs or CS peptides
| Antigen | Group | CD692 | IFN-γ2 | CD253 | |||
|---|---|---|---|---|---|---|---|
| T cells | NK cells | T cells | NK cells | T cells | |||
| HBs |
RTS,S/AS01
E |
n (%) |
29 (36.2) |
51 (63.8) |
30 (37.5) |
37 (46.3) |
27 (49.1) |
| Control | n (%) |
4 (4.1) |
7 (7.1) |
22 (22.5) |
18 (17.5) |
5 (8.2) |
|
| P4 | <0.0001 | <0.0001 | 0.021 | <0.0001 | <0.0001 | ||
| CS |
RTS,S/AS01
E |
n (%) |
6 (7.5) |
11 (13.8) |
13 (16.3) |
21 (26.2) |
5 (9.1) |
| Control | n (%) |
0 (0) |
3 (3.1) |
16 (16.3) |
20 (20.4) |
0 (0) |
|
| P4 | 0.006 | 0.01 | 1.000 | 0.38 | 0.02 | ||
1
Responders are defined as those with a peptide-specific response greater than or equal to twice the value of their own negative control (GM) value
2
CD69 and IFN-γ data are based on 80 RTS,S/AS01E vaccinees and 98 Controls.
3
CD25 data are based on 55 RTS,S/AS01E vaccinees and 61 Controls.
4
Fisher’s exact test