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The influence of TRPV4 inhibitors HC 067047 and RN 1734 on the PI uptake response to hyposmotic Krebs solution (200 mosM). Intact lenses were exposed to hyposmotic solution for 10 min in the presence or absence of either 10 μM HC 067047 (A) or 10 μM RN 1734 (B), added 20 min beforehand. Then the epithelium was removed, homogenized, and assayed for PI. Values are means ± SE of results from 6–9 lenses. ***P < 0.001, significant difference from control.
