Figure A1.

A supplementary whole-brain analysis of radial diffusivity change among patients that was not restricted to regions demonstrating an FA effect was conducted. This analysis was carried out in the same radial diffusivity factorial model used in the restricted radial diffusivity analyses, and statistical thresholds used in FA analyses were employed. This analysis examined decreases in radial diffusivity during the four year study duration. Regions of decreased radial diffusivity included significant longitudinal decreases in radial diffusivity in superior and inferior longitudinal fasiculi, internal and external capsules, forceps major and minor and the descending corticospinal tract (blue). The tubular regions of change that extend through the descending corticospinal tract were not constrained on any side by the white matter mask employed in our analyses. The left side of the statistical map is patient left and right is patient right.