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. 2012 Apr 19;302(12):G1405–G1415. doi: 10.1152/ajpgi.00543.2011

Fig. 1.

Fig. 1.

Signal transducer and activator of transcription 1 (STAT1) hyperactivation is linked to T cell accumulation in the colonic mucosa of human ulcerative colitis (UC) specimens. Immunohistochemical staining of CD3+ T cells (A), and cytoplasmic (cSTAT1) and nuclear (pSTAT1) protein (B) in normal colon tissues and colonic tissue specimens of human patients with UC. CD3 and STAT1 immunoreactivity is shown as the brown color, whereas cells that are unreactive are indicated by the blue counterstain. Shown are representative images. a and c: Normal colon tissues from patients with colon cancer b and d: colon tissues from human patients with UC. 1: Image of entire tissue microarray (TMA) tissue disc; 2: high magnification of 1. C: quantification of the number of CD3+ T cells and STAT1-positive cells in the colon tissues. The number of CD3+ T cells in each specimen printed on the TMA was counted, and cSTAT1 and nSTAT1 were scored. Left: difference in the number of T cells between normal (n = 7) and UC (n = 6) colon tissues. Middle: difference in the percentage of cSTAT1-positive colonic epithelial cells between normal and UC colon tissues. Right: difference in the percent of nSTAT1-positive colonic epithelial cells between normal and UC colon tissues.