Table 1.

Outline of the major renin-angiotensin system enzymes indicating their corresponding cleaving sites within the angiotensin peptide sequence

		APA ↓												TOP PEP NEP ↓		Cathepsin G Tonin Chymase ACE ↓		Cathepsin A CPA ACE2 ↓		Mol. Wt.
ANG I	Asp	—	Arg	—	Val	—	Tyr	—	Ile	—	His	—	Pro	—	Phe	—	His	—	Leu	1,296
ANG-(2-10)			Arg	—	Val	—	Tyr	—	Ile	—	His	—	Pro	—	Phe	—	His	—	Leu	1,181
ANG-(1-9)	Asp	—	Arg	—	Val	—	Tyr	—	Ile	—	His	—	Pro	—	Phe	—	His			1,183
ANG-II	Asp	—	Arg	—	Val	—	Tyr	—	Ile	—	His	—	Pro	—	Phe					1,046
ANG-(1-7)	Asp	—	Arg	—	Val	—	Tyr	—	Ile	—	His	—	Pro							899

		DAPAPA↓												PCPPEPACE2 ↓
ANG II	Asp	—	Arg	—	Val	—	Tyr	—	Ile	—	His	—	Pro	—	Phe					1,046
ANG III			Arg	—	Val	—	Tyr	—	Ile	—	His	—	Pro	—	Phe					931
ANG-(1-7)	Asp	—	Arg	—	Val	—	Tyr	—	Ile	—	His	—	Pro							899

				APBAPN ↓
ANG III			Arg	—	Val	—	Tyr	—	Ile	—	His	—	Pro	—	Phe					931
ANG IV					Val	—	Tyr	—	Ile	—	His	—	Pro	—	Phe					665
Amino acid position	1		2		3		4		5		6		7		8		9		10

ANG, angiotensin; APA, aminopeptidase A; TOP, thimet oligopeptidase; PEP, prolylendopeptidase; NEP, neprilysin; ACE, angiotensin-converting enzyme; CPA, carboxypeptidase A; ACE2, angiotensin-converting enzyme 2; DAP, aspartyl aminopeptidase; PCP, prolylcarboxypeptidase, APB, aminopeptidase B; APN, aminopeptidase N.