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. 2009 Jun;1(3):152–165. doi: 10.1002/emmm.200900024

Figure 2. PINK1 and respiration.

Figure 2

Loss of PINK1 function impairs mitochondrial respiration, results in reduced ATP production and increased ROS levels. The increase in ROS inhibits the glucose transporter and could induce mutations within mitochondrial DNA. Impairment of the glucose transporter reduces substrate delivery to complexes I and II of the respiratory chain. As a direct consequence, ATP synthase is forced to consume, rather than produce, ATP in order to maintain the mitochondrial membrane potential.