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. 2009 Sep;1(6-7):315–322. doi: 10.1002/emmm.200900041

Figure 4. PARP inhibitor sensitivity in human tumour cells.

Figure 4

A, B. Wild type and catalytically inactive PTEN, both restore PARP inhibitor resistance, as does expression of RAD51; SFs in PC3 cells infected with PTEN wild type, PTEN p.C124S or RAD51 cDNA expression constructs was significantly different than in PC3 + empty vector (p < 0.05, two-way ANOVA). PC3 cells infected with p.K289E cDNA expression construct did not cause significant resistance. PTEN null PC3 cells were infected with cDNA expression constructs as shown and exposed to PARP inhibitor. Western blot and survival curves are shown.