Table 1.

Conservation of genetics of human disease in popular model organisms for protein aggregation research

‘Proteins encoded in genome’ indicates the estimated number of proteins encoded by the genome; for yeast, C. elegans and Drosophila the estimations from Rubin et al (2000) were used, for mouse, the Mouse Genome Informatics from Jackson Laboratory (http://jax.bioinformatics.org; September 2009), and for human the estimation from the International Genome Sequencing Consortium. The human disease homology indicates the number of genetic orthologue clusters to human disease genes, relating to the number of orthologues in that model organism of human disease genes, a measure for the genetic conservation of human disease genes (O'Brien et al, 2004, Human Mutation; http://orthodisease.cgb.ki.se).