Fig. 2.

Esophageal stricture in IL-5-induced esophageal inflammation. The WT and CD2-IL-5 mice were given 10% barium sulfate solution orally via a 5-ml syringe. Mice were allowed to slowly swallow ∼3–4 ml of the solution and then anesthetized with isoflurane. X-ray analysis was performed on the whole body. Radiological barium-swallowing experiments indicated esophageal stricture in CD2-IL-5 mice develops in response to IL-5-induced chronic inflammation in the esophagus. Representative radiophotographs of WT (A and B) and CD2-IL-5 (C–E) mice are shown. Esophageal stricture is marked by the arrows for the CD2-IL-5 mice; no stricture is visible in WT mice. For WT and CD2-IL5 mice, n = 8–10/group. TG, transgenic.