Fig. 7.
Esophageal motility impairment is independent of eosinophilic inflammation. The concentration-dependent, carbachol-induced contraction of esophageal longitudinal muscle and isoproterenol-induced relaxation of carbachol-precontracted (105 M) esophageal longitudinal muscle contraction was measured in WT, CD2-IL-5, and ΔdblGATA/CD2-IL-5 mice by adding increasing concentrations of carbachol or isoproterenol, as indicated (A and B). Esophageal muscle contraction and relaxation in CD2-IL-5 mice is impaired compared with WT mice; comparable esophageal motility impairment is shown between CD2-IL-5 TG and ΔdblGATA/CD2-IL-5 TG mice (A and B). Data are given as means ± SE, n = 6 mice/group, P < 0.001.