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Mkp-1/Il-10 double knockout mice develop periocular lesions. Mkp-1+/+/Il-10+/+, Mkp-1−/−/Il-10+/+, Mkp-1+/+/Il-10−/−, and Mkp-1−/−/Il-10−/− mice were housed in a SPF environment and scored for grossly visible eye abnormality over 6 mo. A: representative images of periocular swelling in Mkp-1/Il-10 double knockout mice. B: time course of the development of periocular lesions. Graphical representation showing the percentage of mice that develop ocular disease (n = 12 for each genotype).
