Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Mar 29;302(11):G1322–G1335. doi: 10.1152/ajpgi.00018.2012

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2012 the American Physiological Society

PMC Copyright notice

Fig. 6. — Double knockout mice exhibit conjunctival and eyelid lesions. Mkp-1^+/+/Il-10^+/+, Mkp-1^−/−/Il-10^+/+, Mkp-1^+/+/Il-10^−/−, and Mkp-1^−/−/Il-10^−/− mice were housed in a SPF environment and were euthanized at 3 mo of age. Eyes and periocular tissues were excised, routinely fixed, and embedded, and sections were stained with H&E. A: conjunctival lesions in double knockout mice. Mkp-1^+/+/Il-10^+/+ mice lacked conjunctival lesions (top row). Mkp-1^−/−/Il-10^+/+ and Mkp-1^+/+/Il-10^−/− mice showed moderately increased goblet cell numbers and mild increased mucus accumulation in the conjunctival space (2nd and 3rd rows). The conjunctival mucosa of Mkp-1^−/−/Il-10^−/− mice was markedly thickened with moderate goblet cell hyperplasia and moderate to marked mucus accumulation in the conjunctival space (bottom row). Additionally, the conjunctival stroma was expanded by mild edema and infiltrated by neutrophils, with fewer lymphocytes and plasma cells. B: eyelid lesions in Mkp-1/Il-10 double knockout mice. The haired skin of double knockout mouse eyelids mice was markedly thickened and infiltrated by lymphocytes and plasma cells, with scattered clusters of mast cells. Wild-type, Mkp-1^−/−/Il-10^+/+, or Mkp-1^+/+/Il-10^−/− mouse eyelids lacked lesions. Column on the right contains high-resolution images of the boxed areas in left column.