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Apoptotic activity increases with downregulation of the CCK-BR. A: caspase-3 activity increases in cells transfected with CCK-BR siRNA. Results are standardized to vehicle, n = 7. B: caspase-3 activity is increased in CCK-BR shRNA clones. Results are standardized to WT, n = 5. C: percentage of TUNEL-positive cells measured by flow cytometry is increased in cells transfected with CCK-BR siRNA, n = 5. ***P < 0.005 and ‡P < 0.001.
