Modulation of miRNA expression is colon specific upon DSS treatment. Expression of miRNA 762, 132, and 92a in the colon changes significantly in DSS-treated WT, Tg, or both animals compared with control, but their expression in spleen and liver remains unchanged or nonsignificant. Values represent means ± SE of n = 6/group. *P < 0.05, **P < 0.005, and ***P < 0.001.