Table 5.
Enriched functional group among the gene targets of colonic miRNAs 132, 429, 200b, and 150 as predicted by DAVID software
| Annotation Cluster | Enrichment Score | Enriched Functional Group Gene Annotation/Function | Total Gene Count |
|---|---|---|---|
| 1 | 3.36 | Nucleus | 68 |
| Repressor | 15 | ||
| Transcription regulation | 34 | ||
| Transcription | 34 | ||
| DNA binding | 27 | ||
| 2 | 2.28 | Mitosis | 24 |
| Cell cycle | 5 | ||
| Nucleus | 20 | ||
| 3 | 2.01 | Ubl conjugation | 15 |
| Cross-link: Glycyl lysine isopeptide | 6 | ||
| Isopeptide bond | 7 | ||
| 4 | 1.74 | LDL-receptor domain class A 1–8 | 24 |
| LDL-receptor repeat class B 1–6 | 18 | ||
| Endocytosis signal | 3 | ||
| Endocytosis | 4 | ||
| EGF-like domain 1–3 | 17 | ||
| 5 | 1.43 | Lipid moiety binding region: GPI-anchor amidated serine | 5 |
| GPI-anchor | 5 | ||
| Lipoprotein | 12 | ||
| Propeptide | 6 | ||
| 6 | 1.14 | EGF-like domain 1,3–8 | 29 |
A total of 238 genes were the potential target of these four miRNAs. Gene groups with enrichment score >1.00 shown above (The higher the enrichment score, the more enriched that particular group).
LDL, low-density lipoprotein; EGF, epidermal growth factor; GPI, glycophosphatidylinositol; Ubl, ubiquitin.